Lactobacillus plantarum CECT7315 and CECT7316 stimulate immunoglobulin production after influenza vaccination in elderly.
Identifieur interne : 000282 ( Main/Exploration ); précédent : 000281; suivant : 000283Lactobacillus plantarum CECT7315 and CECT7316 stimulate immunoglobulin production after influenza vaccination in elderly.
Auteurs : M. Bosch [Espagne] ; M. Méndez ; M. Pérez ; A. Farran ; M C Fuentes ; J. Cu ÉSource :
- Nutricion hospitalaria [ 1699-5198 ]
Descripteurs français
- KwdFr :
- Anticorps antiviraux (analyse), Anticorps antiviraux (biosynthèse), Espagne (MeSH), Femelle (MeSH), Humains (MeSH), Immunisation (MeSH), Immunoglobuline A (biosynthèse), Immunoglobuline G (biosynthèse), Immunoglobulines (biosynthèse), Lactobacillus plantarum (MeSH), Mâle (MeSH), Méthode en double aveugle (MeSH), Probiotiques (usage thérapeutique), Produits laitiers (MeSH), Relation dose-effet des médicaments (MeSH), Sujet âgé (MeSH), Sujet âgé de 80 ans ou plus (MeSH), Vaccins antigrippaux (immunologie).
- MESH :
- analyse : Anticorps antiviraux.
- biosynthèse : Anticorps antiviraux, Immunoglobuline A, Immunoglobuline G, Immunoglobulines.
- immunologie : Vaccins antigrippaux.
- usage thérapeutique : Probiotiques.
- Espagne, Femelle, Humains, Immunisation, Lactobacillus plantarum, Mâle, Méthode en double aveugle, Produits laitiers, Relation dose-effet des médicaments, Sujet âgé, Sujet âgé de 80 ans ou plus.
- Wicri :
- geographic : Espagne.
English descriptors
- KwdEn :
- Aged (MeSH), Aged, 80 and over (MeSH), Antibodies, Viral (analysis), Antibodies, Viral (biosynthesis), Dairy Products (MeSH), Dose-Response Relationship, Drug (MeSH), Double-Blind Method (MeSH), Female (MeSH), Humans (MeSH), Immunization (MeSH), Immunoglobulin A (biosynthesis), Immunoglobulin G (biosynthesis), Immunoglobulins (biosynthesis), Influenza Vaccines (immunology), Lactobacillus plantarum (MeSH), Male (MeSH), Probiotics (therapeutic use), Spain (MeSH).
- MESH :
- chemical , analysis : Antibodies, Viral.
- chemical , biosynthesis : Antibodies, Viral, Immunoglobulin A, Immunoglobulin G, Immunoglobulins.
- chemical , immunology : Influenza Vaccines.
- geographic : Spain.
- therapeutic use : Probiotics.
- Aged, Aged, 80 and over, Dairy Products, Dose-Response Relationship, Drug, Double-Blind Method, Female, Humans, Immunization, Lactobacillus plantarum, Male.
Abstract
OBJECTIVE
The effectiveness of influenza vaccination in preventing illness is lower in the elderly; this is why the ability of Lactobacillus plantarum CECT 7315/7316 to stimulate the response to influenza vaccination in elderly was evaluated.
RESEARCH METHODS AND PROCEDURES
A randomized, double-blind, placebo-controlled human trial including 60 institutionalized volunteers aged 65-85 years was performed. All the volunteers were vaccinated with a trivalent influenza vaccine (A/Wisconsin/67/2005 NYMC X-161B (H3N2), A/Solomon Islands/3/2006 (H1N1) and B/Malaysia/2506/2004) for the Spanish vaccine campaign 2006/2007. The consumption of the probiotic began between three and four months after the vaccination. Volunteers were randomly assigned to one of three following groups: group A (receiving 5*10(9) cfu/day of L. plantarum CECT 7315/7316 in 20 g powdered skim milk), group B (receiving 5*10(8) cfu/day of L. plantarum CECT 7315/7316 in 20 g powdered skim milk) and group C or placebo (20 g powered skim milk). The participants consumed the probiotic during 3 months.
RESULTS
The consumption of L. plantarum CECT 7315/7316 during 3 months after influenza vaccination increased the levels of influenza-specific IgA and IgG antibodies. Moreover, a trend towards an increase in influenza-specific IgM antibodies was also observed.
CONCLUSION
L. plantarum CECT7315/7316 has an immunostimulating effect and could be used to improve the response to influenza vaccination in elderly.
DOI: 10.1590/S0212-16112012000200023
PubMed: 22732975
Affiliations:
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Farran</name></author><author><name sortKey="Fuentes, M C" sort="Fuentes, M C" uniqKey="Fuentes M" first="M C" last="Fuentes">M C Fuentes</name></author><author><name sortKey="Cu E, J" sort="Cu E, J" uniqKey="Cu E J" first="J" last="Cu É">J. 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A, Cerdañola del Vallés, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>AB-Biotics, S. A, Cerdañola del Vallés</wicri:regionArea><wicri:noRegion>Cerdañola del Vallés</wicri:noRegion></affiliation></author><author><name sortKey="Mendez, M" sort="Mendez, M" uniqKey="Mendez M" first="M" last="Méndez">M. Méndez</name></author><author><name sortKey="Perez, M" sort="Perez, M" uniqKey="Perez M" first="M" last="Pérez">M. Pérez</name></author><author><name sortKey="Farran, A" sort="Farran, A" uniqKey="Farran A" first="A" last="Farran">A. Farran</name></author><author><name sortKey="Fuentes, M C" sort="Fuentes, M C" uniqKey="Fuentes M" first="M C" last="Fuentes">M C Fuentes</name></author><author><name sortKey="Cu E, J" sort="Cu E, J" uniqKey="Cu E J" first="J" last="Cu É">J. Cu É</name></author></analytic><series><title level="j">Nutricion hospitalaria</title><idno type="eISSN">1699-5198</idno></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Aged (MeSH)</term><term>Aged, 80 and over (MeSH)</term><term>Antibodies, Viral (analysis)</term><term>Antibodies, Viral (biosynthesis)</term><term>Dairy Products (MeSH)</term><term>Dose-Response Relationship, Drug (MeSH)</term><term>Double-Blind Method (MeSH)</term><term>Female (MeSH)</term><term>Humans (MeSH)</term><term>Immunization (MeSH)</term><term>Immunoglobulin A (biosynthesis)</term><term>Immunoglobulin G (biosynthesis)</term><term>Immunoglobulins (biosynthesis)</term><term>Influenza Vaccines (immunology)</term><term>Lactobacillus plantarum (MeSH)</term><term>Male (MeSH)</term><term>Probiotics (therapeutic use)</term><term>Spain (MeSH)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Anticorps antiviraux (analyse)</term><term>Anticorps antiviraux (biosynthèse)</term><term>Espagne (MeSH)</term><term>Femelle (MeSH)</term><term>Humains (MeSH)</term><term>Immunisation (MeSH)</term><term>Immunoglobuline A (biosynthèse)</term><term>Immunoglobuline G (biosynthèse)</term><term>Immunoglobulines (biosynthèse)</term><term>Lactobacillus plantarum (MeSH)</term><term>Mâle (MeSH)</term><term>Méthode en double aveugle (MeSH)</term><term>Probiotiques (usage thérapeutique)</term><term>Produits laitiers (MeSH)</term><term>Relation dose-effet des médicaments (MeSH)</term><term>Sujet âgé (MeSH)</term><term>Sujet âgé de 80 ans ou plus (MeSH)</term><term>Vaccins antigrippaux (immunologie)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="analysis" xml:lang="en"><term>Antibodies, Viral</term></keywords><keywords scheme="MESH" type="chemical" qualifier="biosynthesis" xml:lang="en"><term>Antibodies, Viral</term><term>Immunoglobulin A</term><term>Immunoglobulin G</term><term>Immunoglobulins</term></keywords><keywords scheme="MESH" type="chemical" qualifier="immunology" xml:lang="en"><term>Influenza Vaccines</term></keywords><keywords scheme="MESH" type="geographic" xml:lang="en"><term>Spain</term></keywords><keywords scheme="MESH" qualifier="analyse" xml:lang="fr"><term>Anticorps antiviraux</term></keywords><keywords scheme="MESH" qualifier="biosynthèse" xml:lang="fr"><term>Anticorps antiviraux</term><term>Immunoglobuline A</term><term>Immunoglobuline G</term><term>Immunoglobulines</term></keywords><keywords scheme="MESH" qualifier="immunologie" xml:lang="fr"><term>Vaccins antigrippaux</term></keywords><keywords scheme="MESH" qualifier="therapeutic use" xml:lang="en"><term>Probiotics</term></keywords><keywords scheme="MESH" qualifier="usage thérapeutique" xml:lang="fr"><term>Probiotiques</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Aged</term><term>Aged, 80 and over</term><term>Dairy Products</term><term>Dose-Response Relationship, Drug</term><term>Double-Blind Method</term><term>Female</term><term>Humans</term><term>Immunization</term><term>Lactobacillus plantarum</term><term>Male</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Espagne</term><term>Femelle</term><term>Humains</term><term>Immunisation</term><term>Lactobacillus plantarum</term><term>Mâle</term><term>Méthode en double aveugle</term><term>Produits laitiers</term><term>Relation dose-effet des médicaments</term><term>Sujet âgé</term><term>Sujet âgé de 80 ans ou plus</term></keywords><keywords scheme="Wicri" type="geographic" xml:lang="fr"><term>Espagne</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p><b>OBJECTIVE</b></p><p>The effectiveness of influenza vaccination in preventing illness is lower in the elderly; this is why the ability of Lactobacillus plantarum CECT 7315/7316 to stimulate the response to influenza vaccination in elderly was evaluated.</p></div><div type="abstract" xml:lang="en"><p><b>RESEARCH METHODS AND PROCEDURES</b></p><p>A randomized, double-blind, placebo-controlled human trial including 60 institutionalized volunteers aged 65-85 years was performed. All the volunteers were vaccinated with a trivalent influenza vaccine (A/Wisconsin/67/2005 NYMC X-161B (H3N2), A/Solomon Islands/3/2006 (H1N1) and B/Malaysia/2506/2004) for the Spanish vaccine campaign 2006/2007. The consumption of the probiotic began between three and four months after the vaccination. Volunteers were randomly assigned to one of three following groups: group A (receiving 5*10(9) cfu/day of L. plantarum CECT 7315/7316 in 20 g powdered skim milk), group B (receiving 5*10(8) cfu/day of L. plantarum CECT 7315/7316 in 20 g powdered skim milk) and group C or placebo (20 g powered skim milk). The participants consumed the probiotic during 3 months.</p></div><div type="abstract" xml:lang="en"><p><b>RESULTS</b></p><p>The consumption of L. plantarum CECT 7315/7316 during 3 months after influenza vaccination increased the levels of influenza-specific IgA and IgG antibodies. Moreover, a trend towards an increase in influenza-specific IgM antibodies was also observed.</p></div><div type="abstract" xml:lang="en"><p><b>CONCLUSION</b></p><p>L. plantarum CECT7315/7316 has an immunostimulating effect and could be used to improve the response to influenza vaccination in elderly.</p></div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">22732975</PMID><DateCompleted><Year>2012</Year><Month>11</Month><Day>13</Day></DateCompleted><DateRevised><Year>2013</Year><Month>07</Month><Day>02</Day></DateRevised><Article PubModel="Print"><Journal><ISSN IssnType="Electronic">1699-5198</ISSN><JournalIssue CitedMedium="Internet"><Volume>27</Volume><Issue>2</Issue><PubDate><MedlineDate>2012 Mar-Apr</MedlineDate></PubDate></JournalIssue><Title>Nutricion hospitalaria</Title><ISOAbbreviation>Nutr Hosp</ISOAbbreviation></Journal><ArticleTitle>Lactobacillus plantarum CECT7315 and CECT7316 stimulate immunoglobulin production after influenza vaccination in elderly.</ArticleTitle><Pagination><MedlinePgn>504-9</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1590/S0212-16112012000200023</ELocationID><ELocationID EIdType="pii" ValidYN="Y">S0212-16112012000200023</ELocationID><Abstract><AbstractText Label="OBJECTIVE" NlmCategory="OBJECTIVE">The effectiveness of influenza vaccination in preventing illness is lower in the elderly; this is why the ability of Lactobacillus plantarum CECT 7315/7316 to stimulate the response to influenza vaccination in elderly was evaluated.</AbstractText><AbstractText Label="RESEARCH METHODS AND PROCEDURES" NlmCategory="METHODS">A randomized, double-blind, placebo-controlled human trial including 60 institutionalized volunteers aged 65-85 years was performed. All the volunteers were vaccinated with a trivalent influenza vaccine (A/Wisconsin/67/2005 NYMC X-161B (H3N2), A/Solomon Islands/3/2006 (H1N1) and B/Malaysia/2506/2004) for the Spanish vaccine campaign 2006/2007. The consumption of the probiotic began between three and four months after the vaccination. Volunteers were randomly assigned to one of three following groups: group A (receiving 5*10(9) cfu/day of L. plantarum CECT 7315/7316 in 20 g powdered skim milk), group B (receiving 5*10(8) cfu/day of L. plantarum CECT 7315/7316 in 20 g powdered skim milk) and group C or placebo (20 g powered skim milk). The participants consumed the probiotic during 3 months.</AbstractText><AbstractText Label="RESULTS" NlmCategory="RESULTS">The consumption of L. plantarum CECT 7315/7316 during 3 months after influenza vaccination increased the levels of influenza-specific IgA and IgG antibodies. Moreover, a trend towards an increase in influenza-specific IgM antibodies was also observed.</AbstractText><AbstractText Label="CONCLUSION" NlmCategory="CONCLUSIONS">L. plantarum CECT7315/7316 has an immunostimulating effect and could be used to improve the response to influenza vaccination in elderly.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Bosch</LastName><ForeName>M</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>AB-Biotics, S. A, Cerdañola del Vallés, Spain.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Méndez</LastName><ForeName>M</ForeName><Initials>M</Initials></Author><Author ValidYN="Y"><LastName>Pérez</LastName><ForeName>M</ForeName><Initials>M</Initials></Author><Author ValidYN="Y"><LastName>Farran</LastName><ForeName>A</ForeName><Initials>A</Initials></Author><Author ValidYN="Y"><LastName>Fuentes</LastName><ForeName>M C</ForeName><Initials>MC</Initials></Author><Author ValidYN="Y"><LastName>Cuñé</LastName><ForeName>J</ForeName><Initials>J</Initials></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D016449">Randomized Controlled Trial</PublicationType><PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType></PublicationTypeList></Article><MedlineJournalInfo><Country>Spain</Country><MedlineTA>Nutr Hosp</MedlineTA><NlmUniqueID>9100365</NlmUniqueID><ISSNLinking>0212-1611</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D000914">Antibodies, Viral</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D007070">Immunoglobulin A</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D007074">Immunoglobulin G</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D007136">Immunoglobulins</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D007252">Influenza Vaccines</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D000368" MajorTopicYN="N">Aged</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000369" MajorTopicYN="N">Aged, 80 and over</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000914" MajorTopicYN="N">Antibodies, Viral</DescriptorName><QualifierName UI="Q000032" MajorTopicYN="N">analysis</QualifierName><QualifierName UI="Q000096" MajorTopicYN="N">biosynthesis</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D003611" MajorTopicYN="N">Dairy Products</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D004305" MajorTopicYN="N">Dose-Response Relationship, Drug</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D004311" MajorTopicYN="N">Double-Blind Method</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D005260" MajorTopicYN="N">Female</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D007114" MajorTopicYN="N">Immunization</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D007070" MajorTopicYN="N">Immunoglobulin A</DescriptorName><QualifierName UI="Q000096" MajorTopicYN="N">biosynthesis</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D007074" MajorTopicYN="N">Immunoglobulin G</DescriptorName><QualifierName UI="Q000096" MajorTopicYN="N">biosynthesis</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D007136" MajorTopicYN="N">Immunoglobulins</DescriptorName><QualifierName UI="Q000096" MajorTopicYN="Y">biosynthesis</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D007252" MajorTopicYN="N">Influenza Vaccines</DescriptorName><QualifierName UI="Q000276" MajorTopicYN="Y">immunology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D048191" MajorTopicYN="Y">Lactobacillus plantarum</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008297" MajorTopicYN="N">Male</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D019936" MajorTopicYN="N">Probiotics</DescriptorName><QualifierName UI="Q000627" MajorTopicYN="Y">therapeutic use</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D013030" MajorTopicYN="N" Type="Geographic">Spain</DescriptorName></MeshHeading></MeshHeadingList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="received"><Year>2011</Year><Month>07</Month><Day>06</Day></PubMedPubDate><PubMedPubDate PubStatus="accepted"><Year>2011</Year><Month>11</Month><Day>15</Day></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2012</Year><Month>6</Month><Day>27</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2012</Year><Month>6</Month><Day>27</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2012</Year><Month>11</Month><Day>14</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">22732975</ArticleId><ArticleId IdType="pii">S0212-16112012000200023</ArticleId><ArticleId 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Cu É</name><name sortKey="Farran, A" sort="Farran, A" uniqKey="Farran A" first="A" last="Farran">A. Farran</name><name sortKey="Fuentes, M C" sort="Fuentes, M C" uniqKey="Fuentes M" first="M C" last="Fuentes">M C Fuentes</name><name sortKey="Mendez, M" sort="Mendez, M" uniqKey="Mendez M" first="M" last="Méndez">M. Méndez</name><name sortKey="Perez, M" sort="Perez, M" uniqKey="Perez M" first="M" last="Pérez">M. Pérez</name></noCountry><country name="Espagne"><noRegion><name sortKey="Bosch, M" sort="Bosch, M" uniqKey="Bosch M" first="M" last="Bosch">M. Bosch</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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